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Age and Ageing Advance Access originally published online on February 28, 2009
Age and Ageing 2009 38(3):283-289; doi:10.1093/ageing/afp011
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© The Author 2009. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Elevated serum advanced glycation end products and their circulating receptors are associated with anaemia in older community-dwelling women

Richard D. Semba1, Luigi Ferrucci2, Kai Sun1, Kushang V. Patel3, Jack M. Guralnik3 and Linda P. Fried1,4

1 Johns Hopkins University School of Medicine, Baltimore, MD, USA
2 Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA
3 Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA
4 Mailman School of Public Health, Columbia University, New York, NY, USA

Address correspondence to: R. Semba. Tel: (+1) 410 955 3572, Fax: (+1) 410 955 0629. Email: rdsemba{at}jhmi.edu

Objective: to determine whether serum carboxymethyl-lysine, a dominant advanced glycation end product (AGE), and circulating total receptor for AGEs (sRAGE) and endogenous secretory receptor for AGEs (esRAGE) are associated with anaemia.

Design: cross-sectional analysis.

Setting: moderately severely disabled women, ≥65 years, living in the community in Baltimore, MD (the Women's Health and Aging Study I).

Participants: 519 women with and without anaemia.

Main outcome measure: haemoglobin and anaemia (haemoglobin <12 g/dL).

Results: of 519 women, 128 (24.7%) had anaemia. All odds ratios (OR) were expressed per one standard deviation. Serum CML was associated with anaemia [OR 1.47, 95% confidence interval (CI) 1.11–1.95, P = 0.008] in a multivariate logistic regression model adjusting for age, race, smoking, education and chronic diseases. Serum sRAGE (ng/mL) and esRAGE (ng/mL) were associated with anaemia (OR 1.52, 95% CI 1.21–1.92, P = 0.0004; OR 1.49, 95% CI 1.18–1.87, P = 0.0006, respectively) in separate multivariate logistic regression models, adjusting for the same covariates mentioned above. Serum CML (P = 0.004), sRAGE (P < 0.0001) and esRAGE (P < 0.0001) were inversely and independently associated with haemoglobin concentrations.

Conclusion: AGEs and circulating RAGE are independently associated with haemoglobin and anaemia in older women. AGEs are amenable to interventions, as serum AGEs can be lowered by a change in dietary pattern and pharmacological treatment.

Keywords: advanced glycation end products, anaemia, haemoglobin, women, elderly

Received 5 June 2008; accepted in revised form 4 December 2008.


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