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© 1978 Oxford University Press

research-article

PICOTAMIDE: EFFECTS ON COAGULATION, FIBRINOLYSIS AND PLATELET AGGREGATION DURING PROLONGED ADMINISTRATION IN THE AGED

R. SCHMUTZLER1, H. HARTMANN1, G. CASALE2 and A. MAGLIANO2

1 Klinik Bergisch-Land, Medizinische Abteilung, 5600 Wuppertal 21, West Germany
2Istituto di Gerontologia e Geriatria dell'Università di Pavia Piazza Borromeo 2, 27100 Pavia, Italy

Picotamide was administered in a daily dose of 1500 mg per os for 30 days to 30 aged, arteriosclerotic subjects and as single doses of 500 mg and 1000 mg to another group of 16 subjects. A reduction of platelet aggregation (methods of Born and Breddin) was observed within 24 hours of commencement of treatment and became more evident in the subsequent days. The reduction was both consistent and significant. A marked increase in fibrinolytic activity (fibrin plate method) was observed during the first 24 hours, particularly for euglobulins with activator.

The reaction and clot formation times (r and k) were prolonged and the maximal amplitude (ma) in thrombelastogram was reduced by a definite, though small amount. After the administration of a single dose the maximal effect was observed after eight hours and was still evident after 48 and, to a lesser degree, after 72 hours. The drug was in all cases well tolerated, without any significant side-effects nor untoward reactions.


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