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© 1979 Oxford University Press

research-article

SYMPOSIUM ON HYPERTENSION IN THE ELDERLY*

PATHOPHYSIOLOGY OF BLOOD PRESSURE IN THE ELDERLY

J. D. SWALES

Department of Medicine, Clinical Sciences Building, Leicester Royal Infirmary P.O. Box 65, Leicester, LE2 7LX

Several of the factors responsible for circulatory control are modified in the elderly. Loss of elasticity of the aortic wall produces a widened pulse pressure and a high incidence of systolic hypertension. Attempts to normalize this may be associated with disabling diastolic hypotension. Arterial baroreceptor sensitivity and responsiveness of the renin-angiotensin system is reduced. Further, the renal capacity to conserve sodium and water is impaired. All these increase the risks associated with antihypertensive treatment, but do not contra-indicate such treatment.


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