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Age and Ageing Advance Access published online on June 25, 2009
Age and Ageing, doi:10.1093/ageing/afp106
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© The Author 2009. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

Spontaneous femoral shaft fracture after long-term alendronate

Tamir Ali1 and Roger H. Jay2

1 Ear, Nose and Throat Department, Freeman Hospital, Newcastle Upon Tyne, NE7 7DN, UK
2 Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK

Address correspondence to: R. H. Jay. Email: Roger.Jay{at}nuth.nhs.uk

Abstract

Alendronate is used as first-line treatment for osteoporosis in postmenopausal women worldwide. The evidence supporting its benefit in reducing the risk of fragility fracture among this high-risk group is well established. Due to its mechanism of action, there were concerns about potential reduction in bone turnover, repair of microdamage and hence reduced bone toughness and increased risk of fractures with long-term use. A number of cases have been reported from other countries describing a pattern of atraumatic mid-femoral fractures in women on long-term alendronate therapy. We present a case of an atraumatic femoral shaft fracture in an elderly woman on long-term alendronate therapy admitted to a UK Hospital.

Keywords: alendronate, femur, fracture, spontaneous, elderly

Received 13 February 2009; accepted in revised form 29 April 2009.


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