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© 1990 Oxford University Press

research-article

Thiamine Status of Healthy and Institutionalized Elderly Subjects: Analysis of Dietary Intake and Biochemical Indices

NICHOLAS P. O'ROURKE, VALDA W. BUNKER*, ANITA J. THOMAS, PAUL M. FINGLAS, ANGELA L. BAILEY and BARBARA E. CLAYTON

University Department of Geriatric Medicine, Faculty of Medicine, Southampton General Hospital Tremona Road, Southampton, Hants SO9 4XY
Nutrition and Food Quality Department, AFRC Institute of Food Research, Norwich Laboratory Colney Lane, Norwich NR4 7UA

*Address correspondence to Dr V. Bunker

Thiamine status was assessed in healthy young and elderly subjects and institutionalized elderly patients by measuring dietary intake, erythrocyte levels of thiamine and the activity of the thiamine-dependent enzyme, erythrocyte transketolase, with and without the addition of excess thiamine pyrophosphate (the TPP effect). Healthy elderly subjects had a reduced intake of thiamine compared with the younger subjects but erythrocyte levels of thiamine and the TPP effect were comparable, suggesting adequate thiamine status. The institutionalized elderly patients had a low intake of thiamine compared with the healthy elderly as well as abnormal biochemical indices suggestive of suboptimal thiamine status Thiamine deficiency does not appear to be a problem in healthy elderly people but those in institutions are at risk of deficiency which might adversely affect their clinical state.

Received December 24, 1989;
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