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© 1994 Oxford University Press

research-article

Eligibility of Acute Stroke Patients for Pharmacological Therapy

B. N. PANAYIOTOU, M. D. FOTHERBY, J. F. POTTER and C. M. CASTLEDEN

Department of Geriatrics, South Wing, Manor Hospital Moat Road, Walsall WS2 9PS
University Department of Medicine, Division of Medicine for the Elderly, Leicester General Hospital, Leicester LE5 4PW

The aims of this study were to analyse the characteristics of patients with acute stroke and to ascertain the number of patients meeting eligibility criteria commonly applied in clinical trials of pharmacological agents for ischaemic stroke. Details of all consecutive admissions with a diagnosis of acute stroke (n = 410, 55% female, mean age 77, range 22–99 years) admitted over a 12-month period to a district general hospital were recorded. Major exclusion criteria used in acute stroke trials were applied to data collected from the study patients. Exclusion criteria were met by 386 (94%) stroke patients, 188 (46%) had admission delay >12 hours, 85 (21%) had pre-existing major disability, 80 (20%) minor stroke, 66 (15%) had coexisting severe illness, 51 (12%) were unconscious, and 30 (7%) had major electrolyte or ECG abnormalities. One hundred and five (26%) had two or more exclusion criteria. The majority of acute stroke patients admitted to a district general hospital would be likely to be excluded from most current pharmacological treatment studies.

Revision received February 22, 1994.
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