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© 1997 Oxford University Press

research-article

The effect of long-term omeprazole on the glucose-hydrogen breath test in elderly patients

STUART HUTCHINSON and ROBERT LOGAN

Portsmouth Healthcare NHS Trust, Queen Alexandra Hospital Portsmouth, UK

Address correspondence to: S. Hutchinson. Fax (+44) 1705 200381

OBJECTIVE:: to test whether omeprazole taken for longer than 1 month causes an increase in the rate of small bowel bacterial overgrowth in elderly subjects.

SUBJECTS:: 44 elderly people, 22 taking omeprazole, 22 not taking omeprazole or H2 receptor antagonists.

MAIN OUTCOME MEASURES:: rate of positive glucose-hydrogen breath tests; anthropometric measures and blood tests reflecting malabsorption.

RESULTS:: there was no difference in the rate of positive tests between those taking omeprazole (45%) and those not taking it (59%). The omeprazole group had significantly lower serum albumin concentrations. There was no difference in body mass index, mid-arm circumference, arm fold thickness, adjusted calcium concentration or haemoglobin levels.

CONCLUSIONS:: omeprazole does not cause increased bacterial small bowel overgrowth in elderly subjects.

Keywords: small bowel bacterial overgrowth, glucose-hydrogen breath test, omeprazole

Received October 7, 1996;
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