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Age and Ageing 2006 35(2):200-201; doi:10.1093/ageing/afj042
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© The Author 2006. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Metformin-related vitamin B12 deficiency

Kin Wah Liu, Lok Kwan Dai and Woo Jean

Medical and Geriatric Unit, Shatin Hospital, New Territories, Hong Kong, China

Address correspondence to: Kin Wah Liu. Email: kwliuhk{at}yahoo.com

Abstract

Metformin is an invaluable hypoglycaemic agent. We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of the cord or anaemia.

Keywords: Metformin, elderly, Vitamin B12 deficiency

Received March 14, 2004; accepted in revised form December 6, 2005.


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