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Age and Ageing 2008 37(2):235; doi:10.1093/ageing/afn005
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Copyright © The Author 2008. Published by Oxford University Press on behalf of the British Geriatrics Society.

Clinical Reminders

Re-infection with primary varicella zoster in older people

Indunil Gunawardena1,* and Thurul Attygalle2

1 Department of Medicine for Elderly People, Queen Alexandra Hospital, Portsmouth, UK
2 Medicine for the Elderly, Colchester General Hospital, UK

* To whom correspondence should be addressed E-mail: indunil.gunawardena{at}nhs.net

Primary chickenpox is rare in older people as there is almost universal seroconversion by early adulthood. Re-infection with chickenpox in the absence of immunosuppression and presence of specific antibodies is even rarer but has been reported [1].

An 82-year-old previously healthy man developed a generalised blistering rash (see Figure 1 in the supplementary data on the journal's website http://www.ageing.oxfordjournals.org) diagnosed by his GP as pemphigus and treated with prednisolone 60 mg daily. He deteriorated and developed pneumonitis and respiratory failure needing high dependency care. Diagnosis of chickenpox was confirmed by positive varicella zoster PCR. His serology showed positive varicella zoster IgG antibodies with a delayed rise in titres by day 29. He responded well to treatment with aciclovir.

Chickenpox should still be considered in the elderly as misdiagnosis and inappropriate treatment delays diagnosis and increases the risk of complications.


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Supplementary data for this article are available online at http://ageing.oxfordjournals.org.


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  1. Gershon AA, Steinberg SP, Gelb L. Clinical reinfection with varicella-zoster virus. J Infect Dis (1984) 149:137–42.[Web of Science][Medline]

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This Article
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