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Age and Ageing Advance Access published online on November 22, 2005
Age and Ageing, doi:10.1093/ageing/afi212
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©The Author 2005. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 16, 2005
Accepted August 24, 2005

Case Report

Intravenous immunoglobulin for resistant Clostridium difficile infection

C. Murphy 1 *, M. Vernon 1, and M. Cullen 1

1 Department of Geriatric Medicine, Wythenshawe Hospital, Manchester, UK

* To whom correspondence should be addressed.
C. Murphy, E-mail: drclmurphy{at}aol.com


  Abstract

Clostridium difficile (CD)-associated diarrhoea and colitis may relapse in up to 20% of treated patients. We present a patient who failed to respond over a 6-month period to treatment either singly or in combination with metronidazole, vancomycin, rifampicin, cholestyramine and probiotics. Her diarrhoea rapidly resolved after a 3-day course of intravenous immunoglobulin. This treatment may compensate for a failed immune response to CD toxin and should be considered for relapsing CD-associated diarrhoea where there is no response to conventional treatment strategies.

Keywords: Clostridium difficile, diarrhoea, immunoglobulin, elderly.
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