Skip Navigation



Age and Ageing Advance Access published online on November 23, 2006
Age and Ageing, doi:10.1093/ageing/afl123
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
36/1/23    most recent
afl123v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Gorospe, E. C.
Right arrow Articles by Dave, J. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gorospe, E. C.
Right arrow Articles by Dave, J. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © The Author 2007. Published by Oxford University Press on behalf of the British Geriatrics Society.
Accepted September 14, 2006

Systematic Review

The risk of dementia with increased body mass index: a systematic review

Emmanuel C. Gorospe 1 and Jatin K. Dave 1 *

1 Division of Aging, Brigham and Women's Hospital/Harvard Medical School, 1620 Tremont Street, Boston, USA

* To whom correspondence should be addressed.
Jatin K. Dave, E-mail: jkdave{at}partners.org


  Abstract

Background: identification of modifiable risk factors is crucial in the prevention of dementia, given its limited treatment options. Studies on increased body mass index (BMI) as a risk factor for dementia show conflicting results.

Methods: we systematically retrieved and reviewed longitudinal population-based studies on increased BMI and dementia using a standard protocol. We searched Medline (1966-2006), Ageline (1978-2006), PsychInfo (1966-2006), CINAHL (1982-2006), and other relevant databases, including the reference lists of the eligible articles for review. Included studies were subjected to a quality assessment protocol.

Results: we identified eight studies that met our selection criteria. These studies covered 1,688 cases of dementia from 28,697 participants. After adjustment for age, smoking, comorbidities, and other confounders, four studies presented significantly increased risk of dementia with elevated BMI.

Conclusion: this systematic review supports the hypothesis that increased BMI is independently associated with increased risk of dementia. Long-term studies to examine the mechanisms underlying the relationship between obesity and dementia are needed.

Keywords: body mass index, dementia, elderly, obesity, systematic reviews.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch NeurolHome page
A. M. Kanaya, K. Lindquist, T. B. Harris, L. Launer, C. Rosano, S. Satterfield, K. Yaffe, and for the Health ABC Study
Total and Regional Adiposity and Cognitive Change in Older Adults: The Health, Aging and Body Composition (ABC) Study
Arch Neurol, March 1, 2009; 66(3): 329 - 335.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. Sabia, M. Kivimaki, M. J Shipley, M. G Marmot, and A. Singh-Manoux
Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study
Am. J. Clinical Nutrition, February 1, 2009; 89(2): 601 - 607.
[Abstract] [Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
N. A. West and M. N. Haan
Body Adiposity in Late Life and Risk of Dementia or Cognitive Impairment in a Longitudinal Community-Based Study
J Gerontol A Biol Sci Med Sci, January 23, 2009; (2009) gln006v1.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
C. Raffaitin, H. Gin, J.-P. Empana, C. Helmer, C. Berr, C. Tzourio, F. Portet, J.-F. Dartigues, A. Alperovitch, and P. Barberger-Gateau
Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia: The Three-City Study
Diabetes Care, January 1, 2009; 32(1): 169 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
M. A. Beydoun, A. Lhotsky, Y. Wang, G. D. Forno, Y. An, E. J. Metter, L. Ferrucci, R. O'Brien, and A. B. Zonderman
Association of Adiposity Status and Changes in Early to Mid-Adulthood With Incidence of Alzheimer's Disease
Am. J. Epidemiol., November 15, 2008; 168(10): 1179 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 Age AgeingHome page
E. Cereda, V. Sansone, G. Meola, and A. E. Malavazos
Increased visceral adipose tissue rather than BMI as a risk factor for dementia
Age Ageing, September 1, 2007; 36(5): 488 - 491.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.