Age and Ageing Advance Access published online on May 30, 2007
Age and Ageing, doi:10.1093/ageing/afm051
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Serum high sensitivity C-reactive protein and cognitive unction in elderly women
1 Kuopio Research Institute of Exercise Medicine, Finland
2 Institute of Biomedicine, Department of Physiology, University of Kuopio, Finland
3 Department of Neuroscience and Neurology, University of Kuopio, Finland
4 Aging Research Center, Karolinska Institutet, Stockholm, Sweden
5 Department of Public Health and General Practice, University of Kuopio, Finland
6 Department of Clinical Nutrition, Kuopio University Hospital and University of Kuopio, Finland
7 Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
8 Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
Address correspondence to: P.Komulainen. Tel: +358 17 288 4422; Fax: +358 17 288 4488. Email: Pirjo.Komulainen{at}uku.fi
Background: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function.
Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women.
Design: a 12-year population-based follow-up study.
Participants: a total of 97 women between 60 and 70 years of age at baseline.
Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery.
Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient ß –0.842, 95% confidence interval –1.602 to –0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient ß –0.817, 95% confidence interval –1.630 to –0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up.
Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
Keywords: cognitive function, high sensitivity CRP, elderly women
Received 16 November 2006; accepted in revised form 16 March 2007.
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