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Age and Ageing Advance Access published online on November 22, 2007
Age and Ageing, doi:10.1093/ageing/afm159
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Copyright © The Author 2007. Published by Oxford University Press on behalf of the British Geriatrics Society.

Review

Clostridium difficile-associated disease: update and focus on non-antibiotic strategies

Ian Thompson

Department of Clinical Gerontology, King's College Hospital, London SE5 9RS, UK

Address correspondence to: Ian Thompson. Email: joscyn{at}hotmail.com

Clostridium difficile-associated disease (CDAD) is a problem of especially the frail elderly. Changes in virulence of prevalent strains in the early years of the new century saw mortality and morbidity increase from historical levels. This article explores non-antibiotic strategies including the use of probiotics. A number of avenues of ongoing research appear to have potential future clinical application. Evidence exists linking acid-inhibiting drugs to an increased risk of CDAD, and the adjunctive use of Saccharomyces boulardii and infection control measures in the treatment of CDAD.

Keywords: Clostridium difficile, probiotics, elderly, Saccharomyces boulardii

Received 7 April 2007; accepted in revised form 12 September 2007.


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