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Age and Ageing Advance Access published online on March 10, 2009
Age and Ageing, doi:10.1093/ageing/afp019
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© The Author 2009. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Review

Heyde syndrome: a common diagnosis in older patients with severe aortic stenosis

M. W. Massyn1 and S. A. Khan2

1 Specialist Registrar, Department of Elderly Care, Lister Hospital, Corey's Mill Lane, Stevenage, Herts SG1 4AB, UK
2 Consultant Physician & Deputy Clinical Director, Department of Elderly Care, Lister Hospital, Corey's Mill Lane, Stevenage, Herts SG1 4AB, UK

Address correspondence to: S. A. Khan. Tel: (+44) 1438 314333, Ext: 4197/5049; Fax: (+44) 1438 781449. Email: shahidak{at}aol.com

Heyde syndrome is a triad of aortic stenosis, an acquired coagulopathy and anaemia due to bleeding from intestinal angiodysplasia. The evidence that aortic stenosis is the root cause of this coagulopathy is compelling. Resolution of anaemia usually follows aortic valve replacement. This article discusses studies linking aortic stenosis with other conditions in the triad as well as diagnosis and management of this complex pathology.

Keywords: aortic stenosis, iron deficiency anaemia, angiodysplasia, gastrointestinal bleeding, elderly

Received 17 September 2008; accepted in revised form 11 January 2009.


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